Selank Research Profile

Selank

TP-7 / Tuftsin analogue Selank

Selank is a synthetic of the immunopeptide , primarily characterised in rodent behavioural models (anxiety, stress, withdrawal) and neurochemistry . Regulatory status varies — research-use context only on this platform.

Dossier overview

research areas

references

handling notes

Mechanism of action

brain-membrane studies have described Selank as a positive allosteric modulator of GABA binding. Rodent studies have associated administration with altered BDNF levels in hippocampus and prefrontal cortex and reduced behavioural anxiety signs.

Research applications

Rodent anxiety and stress models
Withdrawal-syndrome behavioural studies
GABA-binding
Peptide comparisons

Study references

Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.

Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

2022

Konstantinopolsky MA et al. · Bulletin of Experimental Biology and Medicine

Model: In vivo — outbred rats (naloxone-precipitated morphine withdrawal)
Sample: Not reported in abstract

Single Selank administration was associated with reduced withdrawal-syndrome index and attenuated convulsive reactions in the rat withdrawal model used.

PMID 36322304 DOI 10.1007/s10517-022-05624-x

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

2018

Vyunova TV et al. · Protein and Peptide Letters

Model: In vitro — rat brain cell-membrane preparations ([³H]GABA binding)
Sample: Not reported in abstract

Reported behaviour consistent with positive allosteric modulation of GABA binding in isolated brain-membrane preparations.

PMID 30255741 DOI 10.2174/0929866525666180925144511

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017

Kasian A et al. · Behavioural Neurology

Model: In vivo — male Wistar rats (~400 g) under unpredictable chronic mild stress; 2 stress conditions × 4 treatment subgroups
Sample: n=48 total rats (24 rest + 24 stress, 6 per treatment subgroup: saline, Selank, diazepam, Selank+diazepam)

Combined Selank + diazepam administration was associated with the largest anxiety-related behavioural change in the chronic stress model used.

PMID 28280289 DOI 10.1155/2017/5091027

Evidence caveats

Primary literature concentrates within a small set of research groups; broad independent replication is limited.
Findings are model-specific and not equivalent to clinical-trial evidence.

Storage and handling

Store according to protocol requirements with preparation date and condition documented.

Document context when comparing signalling markers.
Use contamination-control procedures for preparation.
Maintain storage logs for prepared samples.

Research Access Confirmation