Section
Study Design First
The model, sample preparation, controls, and measured endpoint should be reviewed before interpreting a study summary. A finding in one model may not transfer to another system.
Section
Separate Observation From Conclusion
A measured marker or pathway association should be described as an observation unless the source supports a stronger interpretation. Neutral summaries reduce the risk of overstating the literature.
Section
Use Plain Limits
Where evidence is preliminary, model-specific, or based on narrow conditions, the limitation should be visible in the summary rather than hidden in technical wording.
References
Each article cites a minimum of two peer-reviewed sources. Citations record model type and reported sample size where the source provides them. Findings are model-specific and must not be extrapolated to therapeutic use.
The Road to Reproducibility in Animal Research
2016
Jilka RL et al. · Journal of Bone and Mineral Research
- Model
- Narrative review
- Sample
- N/A (review)
Outlined common reproducibility failures in animal research and the role of randomisation, blinding, and reporting guidelines.
Methodological Rigor in Preclinical Cardiovascular Studies: Targets to Enhance Reproducibility and Promote Research Translation
2017
Ramirez FD et al. · Circulation Research
- Model
- Systematic methodological survey
- Sample
- N/A (methodology review across a decade of literature)
Quantified gaps in randomisation, blinding, and sample-size estimation in preclinical literature and proposed targeted improvements.