Dossier overview
4
research areas
3
references
3
handling notes
01
Mechanism of action
Acts as an at KISS1R (). Research describes downstream activation of neurons in reproductive-axis models, and in bone-cell studies, GPR54-dependent signalling affecting BMP2 expression and Src dephosphorylation.
02
Research applications
- KISS1R / signalling studies
- Reproductive endocrinology research
- Bone-cell (osteoclast / osteoblast) biology
- Peptide comparison
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
2024
Li Z et al. · Nature Communications
- Model
- In vitro — primary osteoclasts (differentiation in triplicate); in vivo — Kiss1, Gpr54, and Dusp18 conditional/full knockout mice
- Sample
- Gpr54 cKO n=7/group (4F/3M); Kiss1 cKO n=6/group (3F/3M); Dusp18 KO n=5–7/group; OVX experiments n=6/group; in vitro biological triplicates
KP-10 binding to was associated with suppressed osteoclast activity and reduced bone loss via Dusp18-mediated Src dephosphorylation in the models used.
Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation
2018
Son HE et al. · Scientific Reports
- Model
- In vitro — C3H10T1/2 mouse mesenchymal cells; GPR54⁻/⁻ cells
- Sample
- Not reported in abstract
KP-10 treatment was associated with increased osteogenic including BMP2 via -dependent signalling.
Metabolic regulation of kisspeptin — the link between energy balance and reproduction
2020
Navarro VM et al. · Nature Reviews Endocrinology
- Model
- Narrative review
- Sample
- N/A (review)
Reviewed how metabolic factors regulate kisspeptin neurons and the reproductive axis, integrating rodent and human research.
Evidence caveats
- Reproductive-endocrinology human studies typically use short controlled pharmacology designs; chronic-administration human data are limited.
- Bone-biology findings are early-stage and have not been confirmed in human trials.
04
Storage and handling
Maintain in controlled research storage with lot and preparation records available.
- Record - context and sample preparation details.
- Control light, temperature, and moisture exposure during storage.
- Keep peptide records linked to batch documentation.
05
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