Summary section
Fragment Selection
Peptide may be selected to examine a narrower interaction or signalling pattern. The selected fragment should be interpreted separately from the full .
Summary section
Endpoint Selection
studies may examine binding, markers, or time-dependent response patterns in controlled models.
Summary section
Interpretive Limits
A -level observation is not equivalent to a conclusion about broad biological use. Summaries should state the model and endpoint being discussed.
References
Each article cites a minimum of two peer-reviewed sources. Citations record model type and reported sample size where the source provides them. Findings are model-specific and must not be extrapolated to therapeutic use.
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
2024
Li Z et al. · Nature Communications
- Model
- In vitro osteoclast assays (biological triplicate); in vivo — Kiss1, Gpr54, Dusp18 knockout mice (n=5–7/group)
- Sample
- Gpr54 cKO n=7/group; Kiss1 cKO n=6/group; Dusp18 KO n=5–7/group; OVX n=6/group
Reported GPR54 signalling effects on osteoclast activity and bone resorption via Dusp18-mediated Src dephosphorylation.
Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation
2018
Son HE et al. · Scientific Reports
- Model
- In vitro — C3H10T1/2 mouse mesenchymal cells and GPR54⁻/⁻ cells
- Sample
- Not reported in abstract
Reported KP-10-induced osteogenic gene expression including BMP2 dependent on GPR54 signalling.